Valproic acid is prescribed as an anticonvulsant and mood-stabilizing drug to treat to treat convulsions, migraines, etc.
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Valproic acid is used to treat convulsions, migraines and bipolar disorder. Exact mechanisms of its action are unknown. It is supposed that Valproic acid increases levels of the neurotransmitter gamma-aminobutyric acid (GABA) in the brain.
Take exactly as prescribed by your doctor. Do not exceed the recommended dose. The initial dose for Valproate sodium intravenous injection is 10-15 mg/kg/day divided in 4 doses and given every six hours. The maintenance dose is 30 to 60 mg/kg/day divided in four doses and given every six hours.
Use of valproate sodium injection for periods of more than fortnight has not been studied. Injections of Valporate sodium should be replaced by oral valproate products as soon as possible.
Valporic acid in very rare cases may cause life-threatening liver failure which are most prone to are children under two years old. If children take more than one seizure medication they may be at more risk for liver problems. The risk also increases if they have a brain disease causing mental impairment (, multiple sclerosis, Creutzfeldt-Jacob disease, Huntington disease, a brain injury or infection).
Valproic acid may also cause life-threatening pancreatitis which starts suddenly even when treatment with Valporic acid has been performed for several years. If the following symptoms of early liver damage appear seek immediate medical help: stomach pain, nausea, vomiting, loss of appetite, dark urine, clay-colored stools, low fever, jaundice. Inform your doctor if you are pregnant or plan to become pregnant as this drug is able to cause birth defects. Presence of suicidal thoughts is possible during treatment with Valporic acid. If your mood or behavior change, you have depression, anxiety, hostile, hyperactive or have thoughts about hurting yourself and suicide notify your doctor.
Valporic acid cannot be administered to patients with known hypersensitivity to the medication or urea cycle disorders.
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